Comparison 18. Single agent BRAF inhibitor.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
18.1 Overall survival	2	925	Hazard Ratio (IV, Random, 95% CI)	0.40 [0.28, 0.57]
18.2 Progression‐free survival	2	925	Hazard Ratio (IV, Random, 95% CI)	0.27 [0.21, 0.34]
18.3 Tumour response	2	925	Risk Ratio (M‐H, Random, 95% CI)	6.78 [4.84, 9.49]
18.4 Toxicity (≥ G3)	2	925	Risk Ratio (M‐H, Random, 95% CI)	1.27 [0.48, 3.33]