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. 2018 Feb 6;2018(2):CD000459. doi: 10.1002/14651858.CD000459.pub3

Summary of findings 2. Antipsychotic cessation compared with antipsychotic maintenance for antipsychotic‐induced tardive dyskinesia.

Antipsychotic cessation compared with antipsychotic maintenance for antipsychotic‐induced tardive dyskinesia
Patient or population: psychiatric patients with antipsychotic‐induced tardive dyskinesia
 Setting: inpatients and outpatients in any country
 Intervention: Antipsychotic cessation
 Comparison: Antipsychotic maintenance
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Antipsychotic maintenance Antipsychotic cessation
There is no evidence about the effects of withdrawal of antipsychotics compared with continuation of antipsychotics; none of the included studies evaluated this comparison.  
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: confidence interval
GRADE Working Group grades of evidence
 High quality: we are very confident that the true effect lies close to that of the estimate of the effect
 Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
 Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
 Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect