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. 2018 Feb 6;2018(2):CD000459. doi: 10.1002/14651858.CD000459.pub3

Comparison 2. Switch to specific antipsychotic vs antipsychotic cessation.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Tardive dyskinesia: no clinically important improvement (medium term) 1 42 Risk Ratio (M‐H, Fixed, 95% CI) 0.45 [0.23, 0.89]
2 Tardive dyskinesia: average endpoint score (AIMS, high = poor) (medium term) 1 42 Mean Difference (IV, Fixed, 95% CI) ‐5.5 [‐8.60, ‐2.40]
3 General mental state: average endpoint score (BPRS, high = poor) (medium term) 1 42 Mean Difference (IV, Fixed, 95% CI) ‐4.30 [‐10.48, 1.88]
4 Acceptability of the treatment: leaving the study early (medium term) 1 50 Risk Ratio (IV, Fixed, 95% CI) 0.6 [0.16, 2.25]
5 Adverse effects: use of antiparkinsonism drugs (medium term) 1 48 Risk Ratio (IV, Fixed, 95% CI) 2.08 [0.74, 5.86]
5.1 Haloperidol 1 12 Risk Ratio (IV, Fixed, 95% CI) 2.0 [0.56, 7.09]
5.2 Risperidone 1 36 Risk Ratio (IV, Fixed, 95% CI) 2.26 [0.37, 13.60]
6 Adverse effects: parkinsonism ‐ average endpoint score (ESRS) (medium term) 1 42 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐1.25, 0.45]
7 Adverse effects: dystonia ‐ average endpoint score (ESRS) (medium term) 1 42 Mean Difference (IV, Fixed, 95% CI) ‐0.70 [‐1.76, 0.36]