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. 2018 Feb 28;2018(2):CD011809. doi: 10.1002/14651858.CD011809.pub2

Von Wolff 2009.

Methods Parallel group study
Number of women randomised: 168 (84 in the intervention group; 84 in the control group)
Number of cancellations: 31 cycles (14 in the intervention group, 17 in the control group) which did not reach embryo transfer
Number of cycles analysed: 133
Participants Country of authors: Germany
Inclusion criteria: women aged 18 to 42 years, in a stable relationship
Exclusion criteria: cancellation of embryo transfer due to total fertilisation failure or pending OHSS, Hepatitis B, or C or HIV infection or leukocytospermia in the male partner, seminal plasma volume < 0.5 ml
Mean age (SD not reported): intervention group: 34.4 years; control group: 34.1 years
Mean duration of infertility: not reported
Women with primary infertility: not reported
Setting: ART Center of the Women's University Hospital, Heidelberg, Germany
Interventions Intervention: 0.5 ml seminal plasma application into the cervical canal by an intrauterine insemination catheter right after oocyte pick‐up. The rest of SP was applied at the posterior fornix.
Comparator: saline application in the same way.
Outcomes Clinical pregnancy
Notes We tried to contact the authors by email, twice one month apart, however did not receive a response.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Stratified, block randomisation using lists
Allocation concealment (selection bias) Unclear risk Authors did not report that allocation concealment was used during the trial
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Identical looking placebo was used
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Objective outcome measure
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 10 to 30% attrition with reasons. Similar rate between the two groups
Selective reporting (reporting bias) Low risk Clinical pregnancy rate reported
Other bias Low risk No other cause of potential bias identified