Yatham 2003.
Methods | Allocation: multicentre, randomised, placebo‐controlled trial Blindness: described as "double blind" Duration: 52 weeks Setting: Canadain and Brazilian academic centres |
Participants | Bipolar I disorder in remission from recent manic or mixed episode on treatment with mood stabiliser (valproate or lithium) and either risperidone or olanzapine (N = 159, not clear how many had psychotic features). Total of 39% (62/159) of total sample had co‐occurring alcohol or substance use disorder. |
Interventions | Discontinuation of risperidone or olanzapine at either 0 weeks, 24 weeks or 52 weeks and substitution with placebo. |
Outcomes | Time to any mood episode, YMRS, HAMD‐21, MADRS, CGI‐BP, CGI‐S, Side‐effects UKU scale, ESRS, weight, metabolic measures (glucose, lipid profile). |
Notes | Authors contacted. Responded that no data or analyses available at present for subgroups. No information provided on how many participants had bipolar type I with psychotic features. |