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. 2018 Feb 1;2018(2):CD004876. doi: 10.1002/14651858.CD004876.pub4

Comparison 2. Influenza vaccines versus placebo: randomised controlled trials ‐ parenteral vaccine ‐ adverse events.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 General malaise 4 2560 Risk Ratio (M‐H, Random, 95% CI) 1.18 [0.87, 1.61]
2.2 Nausea 1 672 Risk Ratio (M‐H, Random, 95% CI) 1.75 [0.74, 4.12]
2.3 Upper respiratory tract symptoms 2 713 Risk Ratio (M‐H, Random, 95% CI) 1.35 [0.90, 2.01]
2.4 Headache 3 2519 Risk Ratio (M‐H, Random, 95% CI) 1.10 [0.76, 1.58]
2.5 Fever 3 2519 Risk Ratio (M‐H, Random, 95% CI) 1.57 [0.92, 2.71]
2.6 Local tenderness/sore arm 4 2560 Risk Ratio (M‐H, Random, 95% CI) 3.56 [2.61, 4.87]
2.7 Swelling ‐ erythema ‐ induration 2 1847 Risk Ratio (M‐H, Random, 95% CI) 8.23 [3.98, 17.05]