1	Randomized controlled trial/
2	Controlled clinical study/
3	Random$.ti,ab.
4	randomization/
5	intermethod comparison/
6	placebo.ti,ab.
7	(compare or compared or comparison).ti.
8	(open adj label).ti,ab.
9	((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab.
10	double blind procedure/
11	parallel group$1.ti,ab.
12	(crossover or cross over).ti,ab.
13	((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.
14	(assigned or allocated).ti,ab.
15	(controlled adj7 (study or design or trial)).ti,ab.
16	(volunteer or volunteers).ti,ab.
17	trial.ti.
18	or/1‐17
19	exp breast/
20	exp breast disease/
21	(19 or 20) and exp neoplasm/
22	exp breast tumor/
23	exp breast cancer/
24	exp breast carcinoma/
25	(breast$ adj5 (neoplas$ or cancer$ or carcin$ or tumo$ or metasta$ or malig$)).ti,ab.
26	or/21‐25
27	exp cyclin dependent kinase inhibitor/
28	cyclin dependent kinase$ inhibit$.mp.
29	exp cyclin dependent kinase 4/
30	cyclin dependent kinase 4.mp.
31	exp cyclin dependent kinase 6/
32	cyclin dependent kinase 6.mp.
33	exp palbociclib/
34	palbociclib.mp.
35	exp ribociclib/
36	ribociclib.mp.
37	exp abemaciclib/
38	abemaciclib.mp.
39	or/27‐38
40	18 and 26 and 39
41	limit 40 to (human and (conference abstracts or embase))