Summary of findings 3. Infraorbital nerve block compared with infiltration of the incision for cleft lip repair in children.
| Infraorbital nerve block compared with infiltration of the incision for cleft lip repair in children | |||||
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Patient or population: children with cleft lip Settings: hospital Intervention: infraorbital nerve block Comparison: infiltration of the incision | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| Infiltration of the incision | Infraorbital nerve block | ||||
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Pain score control |
No numeric data available; one study reported difference favouring control group only at 6 hourspostoperatively. One study reported that children in the intervention group had lower pain scores between 1 and 8 hours after the surgery | ||||
| Duration of postoperative analgesia | This outcome was not reported | ||||
| Adverse events | Of the 2 included studies, one study reported no difference between groups, and the other study did not report this outcome | ||||
| Supplemental analgesic requirements | 1000 per 1000 | 160 per 1000 (50 to 510) | RR 0.16 (0.05 to 0.51) |
30 (1) |
⊕⊝⊝⊝ verylow 1,2,3 |
| Time to feeding after surgery | This outcome was not reported | ||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Downgraded one level: few studies with small sample size.
2Downgraded one level due to risk of bias: randomisation and allocation concealment procedures were unclear.
3Downgraded one level due to uncertainty in outcome measurement.