1 Overall survival (6 months) |
2 |
99 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
2 Overall survival (12 months) |
1 |
59 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
3 Overall survival (24 months) |
1 |
37 |
Risk Ratio (M‐H, Random, 95% CI) |
0.23 [0.01, 4.55] |
4 Adverse events‐musculoskeletal |
2 |
91 |
Risk Ratio (M‐H, Random, 95% CI) |
19.03 [1.17, 310.52] |
5 Cancer‐specific survival (6 months) |
2 |
99 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
6 Cancer‐specific survival (12 months) |
1 |
59 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
7 Cancer‐specific survival (24 months) |
1 |
37 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
8 Weight loss (6 months) |
3 |
131 |
Mean Difference (IV, Random, 95% CI) |
‐1.88 [‐5.98, 2.21] |
9 Weight loss stratified by BMI (6 months) |
2 |
101 |
Mean Difference (IV, Random, 95% CI) |
‐3.11 [‐9.32, 3.10] |
9.1 BMI <40 kg/m2
|
2 |
63 |
Mean Difference (IV, Random, 95% CI) |
‐3.18 [‐10.29, 3.93] |
9.2 BMI >/40 kg/m2
|
2 |
38 |
Mean Difference (IV, Random, 95% CI) |
‐2.89 [‐15.65, 9.88] |
10 Weight loss (12 months) |
2 |
91 |
Mean Difference (IV, Random, 95% CI) |
‐8.98 [‐19.88, 1.92] |
11 Weight loss stratified by BMI (12 months) |
2 |
90 |
Mean Difference (IV, Random, 95% CI) |
‐5.23 [‐11.59, 1.12] |
11.1 BMI <40 kg/m2
|
2 |
55 |
Mean Difference (IV, Random, 95% CI) |
‐4.08 [‐11.20, 3.04] |
11.2 BMI >/40 kg/m2
|
2 |
35 |
Mean Difference (IV, Random, 95% CI) |
‐9.76 [‐23.84, 4.32] |
12 Weight loss (24 months) |
1 |
25 |
Mean Difference (IV, Random, 95% CI) |
‐18.26 [‐38.73, 2.21] |
13 Weight loss stratified by BMI (24 months) |
1 |
25 |
Mean Difference (IV, Random, 95% CI) |
‐25.84 [‐81.40, 29.72] |
13.1 BMI <40 kg/m2
|
1 |
13 |
Mean Difference (IV, Random, 95% CI) |
2.12 [‐20.82, 25.06] |
13.2 BMI >/40 kg/m2
|
1 |
12 |
Mean Difference (IV, Random, 95% CI) |
‐54.58 [‐80.97, ‐28.19] |
14 Adverse events‐diarrhoea |
2 |
91 |
Risk Ratio (M‐H, Random, 95% CI) |
4.53 [0.23, 90.51] |
15 Cardiovascular and metabolic event frequency (6 months) |
3 |
131 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
16 Cardiovascular and metabolic event frequency (12 months) |
2 |
93 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
17 Quality of life‐SF12 Physical Health component (6 months) |
1 |
30 |
Mean Difference (IV, Random, 95% CI) |
‐2.29 [‐7.34, 2.76] |
18 Quality of life FACT‐G (6 months) |
2 |
95 |
Mean Difference (IV, Random, 95% CI) |
2.51 [‐5.61, 10.64] |
19 Quality of life stratified by BMI (6 months FACT‐G) |
2 |
95 |
Mean Difference (IV, Random, 95% CI) |
4.69 [1.39, 7.99] |
19.1 BMI <40 kg/m2
|
2 |
60 |
Mean Difference (IV, Random, 95% CI) |
4.01 [‐5.48, 13.51] |
19.2 BMI >/40 kg/m2
|
2 |
35 |
Mean Difference (IV, Random, 95% CI) |
4.18 [‐0.13, 8.49] |
20 Quality of life FACT‐G (12 months) |
2 |
89 |
Mean Difference (IV, Random, 95% CI) |
2.77 [‐0.65, 6.20] |
21 Quality of life stratified by BMI (12 months FACT‐G) |
2 |
89 |
Mean Difference (IV, Random, 95% CI) |
2.83 [0.15, 5.50] |
21.1 BMI <40k g/m2
|
2 |
56 |
Mean Difference (IV, Random, 95% CI) |
2.90 [‐0.40, 6.20] |
21.2 BMI >/40 kg/m2
|
2 |
33 |
Mean Difference (IV, Random, 95% CI) |
2.68 [‐1.90, 7.26] |