Comparison 1. Lifestyle intervention versus. usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival (6 months)	2	99	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2 Overall survival (12 months)	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Overall survival (24 months)	1	37	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.01, 4.55]
4 Adverse events‐musculoskeletal	2	91	Risk Ratio (M‐H, Random, 95% CI)	19.03 [1.17, 310.52]
5 Cancer‐specific survival (6 months)	2	99	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
6 Cancer‐specific survival (12 months)	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
7 Cancer‐specific survival (24 months)	1	37	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
8 Weight loss (6 months)	3	131	Mean Difference (IV, Random, 95% CI)	‐1.88 [‐5.98, 2.21]
9 Weight loss stratified by BMI (6 months)	2	101	Mean Difference (IV, Random, 95% CI)	‐3.11 [‐9.32, 3.10]
9.1 BMI <40 kg/m2	2	63	Mean Difference (IV, Random, 95% CI)	‐3.18 [‐10.29, 3.93]
9.2 BMI >/40 kg/m2	2	38	Mean Difference (IV, Random, 95% CI)	‐2.89 [‐15.65, 9.88]
10 Weight loss (12 months)	2	91	Mean Difference (IV, Random, 95% CI)	‐8.98 [‐19.88, 1.92]
11 Weight loss stratified by BMI (12 months)	2	90	Mean Difference (IV, Random, 95% CI)	‐5.23 [‐11.59, 1.12]
11.1 BMI <40 kg/m2	2	55	Mean Difference (IV, Random, 95% CI)	‐4.08 [‐11.20, 3.04]
11.2 BMI >/40 kg/m2	2	35	Mean Difference (IV, Random, 95% CI)	‐9.76 [‐23.84, 4.32]
12 Weight loss (24 months)	1	25	Mean Difference (IV, Random, 95% CI)	‐18.26 [‐38.73, 2.21]
13 Weight loss stratified by BMI (24 months)	1	25	Mean Difference (IV, Random, 95% CI)	‐25.84 [‐81.40, 29.72]
13.1 BMI <40 kg/m2	1	13	Mean Difference (IV, Random, 95% CI)	2.12 [‐20.82, 25.06]
13.2 BMI >/40 kg/m2	1	12	Mean Difference (IV, Random, 95% CI)	‐54.58 [‐80.97, ‐28.19]
14 Adverse events‐diarrhoea	2	91	Risk Ratio (M‐H, Random, 95% CI)	4.53 [0.23, 90.51]
15 Cardiovascular and metabolic event frequency (6 months)	3	131	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
16 Cardiovascular and metabolic event frequency (12 months)	2	93	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
17 Quality of life‐SF12 Physical Health component (6 months)	1	30	Mean Difference (IV, Random, 95% CI)	‐2.29 [‐7.34, 2.76]
18 Quality of life FACT‐G (6 months)	2	95	Mean Difference (IV, Random, 95% CI)	2.51 [‐5.61, 10.64]
19 Quality of life stratified by BMI (6 months FACT‐G)	2	95	Mean Difference (IV, Random, 95% CI)	4.69 [1.39, 7.99]
19.1 BMI <40 kg/m2	2	60	Mean Difference (IV, Random, 95% CI)	4.01 [‐5.48, 13.51]
19.2 BMI >/40 kg/m2	2	35	Mean Difference (IV, Random, 95% CI)	4.18 [‐0.13, 8.49]
20 Quality of life FACT‐G (12 months)	2	89	Mean Difference (IV, Random, 95% CI)	2.77 [‐0.65, 6.20]
21 Quality of life stratified by BMI (12 months FACT‐G)	2	89	Mean Difference (IV, Random, 95% CI)	2.83 [0.15, 5.50]
21.1 BMI <40k g/m2	2	56	Mean Difference (IV, Random, 95% CI)	2.90 [‐0.40, 6.20]
21.2 BMI >/40 kg/m2	2	33	Mean Difference (IV, Random, 95% CI)	2.68 [‐1.90, 7.26]