3. Mental state: 1.2 General ‐ Average general/overall symptoms score (PANSS total, negative MD favours NRI) ‐ medium‐term (13‐26wks) ‐ Exploration of heterogeneity.

Subgroup or sensitivity analysis (see text for details)	Number of trials	N	Mean difference	95% Confidence interval	I²
Overall outcome	3	219	‐3.67	‐10.07 to 2.72	94%
Excluding outlier; excluding clozapine study	2	112	‐1.07	‐2.59 to 0.46	0%
Fixed‐effect model	3	219	‐3.63	‐4.87 to ‐2.39*	94%

* Statistically significant at p<0.05