2. Sensitivity analysis.
| Comparison | Vaccine type | Study type | Outcome | Age group | Without Russian studies | Data sets | All studies | Data sets |
| Risk ratio (random) (95% CI) | Risk ratio (random) (95% CI) | |||||||
| 01.01 | Live | RCTs | Influenza | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | 0.15 (0.10 to 0.23) | 5 | 0.15 (0.10 to 0.23) | 5 | ||||
| > 6 years | 0.47 (0.23 to 0.97) | 1 | 0.47 (0.23 to 0.97) | 1 | ||||
| Total | 0.18 (0.11 to 0.29) | 6 | 0.18 (0.11 to 0.29) | 6 | ||||
| 01.02 | Live | RCTs | ILI | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | 0.54 (0.12 to 2.42)* | 1 | 0.67 (0.57 to 0.77) | 5 | ||||
| > 6 years | 0.12 (0.01 to 2.11)* | 1 | 0.67 (0.60 to 0.74) | 8 | ||||
| Total | 0.39 (0.10 to 1.48)* | 2 | 0.67 (0.62 to 0.72) | 13 | ||||
| 02.01 | Inactivated | RCTs | Influenza | </= 2 years | 0.55 (0.18 to 1.69) | 2 | 0.55 (0.18 to 1.69) | 2 |
| </= 6 years | 0.61 (0.34 to 1.08) | 2 | 0.61 (0.34 to 1.08) | 2 | ||||
| > 6 years | 0.31 (0.22 to 0.45) | 3 | 0.31 (0.22 to 0.45) | 3 | ||||
| Total | 0.41 (0.29 to 0.59) | 7 | 0.41 (0.29 to 0.59) | 7 | ||||
| 02.02 | Inactivated | RCTs | ILI | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | 0.39 (0.21 to 0.69) | 3 | 0.39 (0.21 to 0.69) | 3 | ||||
| > 6 years | 0.24 (0.08 to 0.70)+ | 2 | 0.72 (0.66 to 0.78) | 4 | ||||
| Total | 0.34 (0.24 to 0.50)+ | 5 | 0.64 (0.54 to 0.76) | 7 | ||||
| 03.01 | Live | Cohort studies | Influenza | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | ‐ | ‐ | ‐ | ‐ | ||||
| > 6 years | ‐ | ‐ | 0.56 (0.35 to 0.91) | 1 | ||||
| Total | No studies | ‐ | 0.56 (0.35 to 0.91) | 1 | ||||
| 03.02 | Live | Cohort studies | ILI | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | ‐ | ‐ | ‐ | ‐ | ||||
| > 6 years | 0.63 (0.57 to 0.69) | 1 | 0.63 (0.57 to 0.69) | 2 | ||||
| Total | 0.63 (0.57 to 0.69) | 1 | 0.63 (0.57 to 0.69) | 2 | ||||
| 04.01 | Inactivated | Cohort studies | Influenza | </= 2 years | 0.63 (0.27 to 1.47) | 3 | 0.63 (0.27 to 1.47) | 3 |
| </= 6 years | 0.34 (0.13 to 0.89) | 1 | 0.34 (0.13 to 0.89) | 1 | ||||
| > 6 years | 0.20 (0.10 to 0.39)* | 1 | 0.36 (0.12 to 1.11) | 2 | ||||
| Total | 0.36 (0.19 to 0.66) | 5 | 0.42 (0.25 to 0.73) | 6 | ||||
| 04.02 | Inactivated | Cohort studies | ILI | </= 2 years | ‐ | ‐ | ‐ | ‐ |
| </= 6 years | 0.40 (0.13 to 1.20) | 3 | 0.81 (0.65 to 1.01) | 4 | ||||
| > 6 years | 0.10 (0.05 to 0.21)+ | 1 | 0.44 (0.29 to 0.68) | 7 | ||||
| Total | 0.26 (0.07 to 0.92)+ | 4 | 0.55 (0.42 to 0.70) | 11 |
CI: confidence interval ILI: influenza‐like illness RCTs: randomised controlled trials *: significance change +: possible decision‐making significant change