| Date | Event | Description |
|---|---|---|
| 31 December 2016 | New search has been performed | For this update we included two new trials (aa Brooks 2016; aa Cowling 2012) and excluded five new trials (Ambrose 2014; Block 2011; Cakir 2012; Cowling 2014; Madhi 2014). |
| 31 December 2016 | New citation required but conclusions have not changed | Our conclusions remain unchanged. |
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