NCT02620150.

Trial name or title	SSRI Effects on Depression and Immunity in HIV/AIDS.
Methods	Randomized controlled trial of escitalopram or placebo with background computerized cognitive behavioural therapy provided to both treatment arms.
Participants	Adults aged ≥ 18 years with HIV infection, on ART and SCID diagnosis of major depression.
Interventions	Escitalopram or placebo with background computerized cognitive behavioural therapy in both treatment arms.
Outcomes	Change in: natural killer cell activity, intracellular interferon gamma, plasma interleukin 6 and plasma C‐reactive protein.
Starting date	January 2016.
Contact information	Dwight L Evans, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA, 19104.
Notes	ClinicalTrials.gov identifier: NCT02620150.

ART: antiretroviral therapy; SCID: Structured Clinical Interview for DSM (Diagnostic and Statistical Manual of Mental Disorders).