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. 2018 Feb 1;2018(2):CD001269. doi: 10.1002/14651858.CD001269.pub6

2. Risk of bias in included studies.

Study design High risk Low risk Unclear risk Total
Case‐control 3 2 18 23
Cohort 14 8 18 40
RCT/CCT 7 12 55 74
Total 24 22 91 137

CCT: controlled clinical trial
 RCT: randomised controlled trial

This table displays the overall methodological quality assessment of the included studies described in the text and represented in extended form (with all items of the tools) in Figure 1.