Comparison 10. Serious adverse events: demyelinating diseases (multiple sclerosis, optic neuritis) ‐ case‐control studies.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Influenza vaccination (seasonal) ‐ general population ‐ demyelinating diseases (unadjusted data)	4	8009	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.79, 1.17]
2 Influenza vaccination (seasonal) ‐ general population ‐ multiple sclerosis (adjusted data)	2		Odds Ratio (Random, 95% CI)	0.76 [0.54, 1.08]
3 Influenza vaccination (seasonal) ‐ general population ‐ optic neuritis (adjusted data)	2		Odds Ratio (Random, 95% CI)	1.03 [0.82, 1.30]