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. 2018 Feb 1;2018(2):CD001269. doi: 10.1002/14651858.CD001269.pub6

Comparison 14. 1968 to 1969 pandemic: inactivated monovalent parenteral influenza vaccine versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Influenza‐like illness 4 4580 Risk Ratio (M‐H, Random, 95% CI) 0.35 [0.25, 0.48]
1.1 WHO recommended parenteral ‐ matching vaccine ‐ 1 dose 4 4226 Risk Ratio (M‐H, Random, 95% CI) 0.35 [0.23, 0.53]
1.2 WHO recommended parenteral ‐ matching vaccine ‐ 2 doses 1 354 Risk Ratio (M‐H, Random, 95% CI) 0.35 [0.22, 0.57]
2 Influenza 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.07 [0.02, 0.31]
2.1 WHO recommended parenteral ‐ matching vaccine 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.07 [0.02, 0.31]
3 Hospitalisations 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.35 [0.13, 0.94]
3.1 WHO recommended parenteral ‐ matching vaccine 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.35 [0.13, 0.94]
4 Pneumonia 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.59 [0.05, 6.51]
4.1 WHO recommended parenteral ‐ matching vaccine 1 1923 Risk Ratio (M‐H, Random, 95% CI) 0.59 [0.05, 6.51]
5 Working days lost 1 1667 Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.60, ‐0.30]
5.1 WHO recommended parenteral ‐ matching vaccine 1 1667 Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.60, ‐0.30]
6 Days ill 1 1667 Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.60, ‐0.30]
6.1 WHO recommended ‐ matching vaccine 1 1667 Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.60, ‐0.30]