aa Mogabgab 1970a.
Methods | Randomised study conducted in the USA during the 1968 to 1969 influenza season. Influenza outbreak lasted 9 weeks, from 9 December to 3 February. Randomisation methods were not described. Laboratory confirmation was obtained (by culture or 4‐fold antibody titre increase in acute convalescent sera) for 20 men randomly selected each week from among the ill. | |
Participants | 1402 airmen previously unvaccinated: 881 vaccinated and 521 given placebo. Age of participants was 18 to 21. | |
Interventions | Monovalent inactivated parenteral influenza A vaccine. Schedule and dose were: single dose. Vaccine composition was: A2/Aichi 2/68 300 CCA units. Placebo was saline for injection. Vaccine was recommended and matched circulating strain. | |
Outcomes | ILI and influenza, complications and admissions. All respiratory illnesses were classified as febrile (38.3 °C or greater), afebrile, pharyngitis, bronchitis, or pneumonia (complications). Surveillance was passive. | |
Notes | Cases occurring during the first 15 days after vaccination were not included in the analysis. Circulating strain was A2/Hong Kong. Efficacy data were extracted. Government funded |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Unclear |
Allocation concealment (selection bias) | Unclear risk | Unclear |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Unclear |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Unclear |
Summary assessment | Unclear risk | Unclear |