aa Monto 2009.

Methods	Third epidemic season (2007 to 2008) of aa Ohmit 2006 and aa Ohmit 2008
Participants	A total of 1952 healthy adults between the ages of 18 and 49 years were enrolled. Some had been also enrolled in the 2 previous seasons.
Interventions	Newly enrolled participants were recruited from the community around 4 university campuses in Michigan. Allocation methods are the same as for aa Ohmit 2006 and aa Ohmit 2008. For the 2007 to 2008 season vaccine composition was the following: Fluzone (Sanofi Pasteur, inactivated trivalent vaccine intramuscular): 15 μg of haemagglutinin from each of the following strains in a 0.5 mL dose: A/Solomon Islands/3/2006 (H1N1), A/Wisconsin/67/2005 (H3N2), and B/Malaysia/2506/2004 (B/Victoria lineage). FluMist (MedImmune, live attenuated vaccine, intranasal): 106.5‐7.5 fluorescent focus units of live attenuated influenza virus reassortants of the same strains as used for the inactivated formulation in a 0.2 mL dose.
Outcomes	Same outcomes as aa Ohmit 2008
Notes	Funding source ‐ mixed
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Unclear
Allocation concealment (selection bias)	Unclear risk	Unclear
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear
Summary assessment	Unclear risk	Unclear