ab Forsyth 1967.

Methods	From this report, only the first phase of the first trial is of interest to this review, in which administration of whole‐virus, oil adjuvanted influenza vaccine Invirin (GSK) was compared with placebo in a semi‐randomised allocation. The trial was performed November to December 1962.
Participants	Medical students (n = 380) at the Queen's University of Belfast, UK
Interventions	Trivalent aqueous vaccine (Invirin) one 0.25 mL dose IM containing strains A/Singapore/1/57, A/England/1/61, B/England/939/59. Placebo (phosphate‐buffered saline) was administered as control. Participants born on odd days were given placebo (n = 186); those born on even days received the vaccine (n = 194).
Outcomes	Local reactions: pain, erythema, tenderness, bruises. Stratified by means of scores ranging from 0 to 3 depending on their severity. Systemic reactions: coryza, migraine, paroxysmal tachycardia. All assessed at days 0, 1, 3, 7, 21 after inoculation. Data refer to a 3‐day follow‐up.
Notes	Safety data only were extracted. Government funded
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Alternate
Allocation concealment (selection bias)	High risk	Not used
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear
Summary assessment	High risk	Unclear