ab Reeve 1982.

Methods	Randomised controlled trial carried out in Wien
Participants	20 university students aged 20 to 24 years
Interventions	1st phase: cold‐recombinant, live flu vaccine II RB‐77 (B/Ann Arbor/1/66 and B/Tecumse/10/77) containing 107.2 EID50 per 0.5 mL dose versus placebo. 1 dose intranasally. During this phase, participants lived under sequestered condition, and close contact between vaccine and placebo recipients was possible. 2nd phase: 3 weeks after the 1st dose all participants were immunised with 1 dose of the same vaccine
Outcomes	During the 5 days following immunisation, participants were medically observed and temperature recorded morning and evening. Occurring symptoms were attributed scores (0 to 3) depending on their severity (no, light, moderate, severe). Fever (oral temperature > 38 °C): 0/10, 0/10; sneezing: 1/10, 0/10; stuffy nose: 7/10, 1/10; running nose: 3/10, 0/10; afebrile subjective symptoms: 8/10, 2/10
Notes	Safety data only were extracted Industry funded
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Unclear
Allocation concealment (selection bias)	Unclear risk	Unclear
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear
Summary assessment	Unclear risk	Unclear