bb Ray 2011.
Methods | Case‐control study | |
Participants | Cases (n = 415): people with diagnosis of definite rheumatoid arthritis based on American College of Rheumatology criteria. Controls (n = 1245): matched for age and number of medical visits before index date. |
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Interventions | Exposure to influenza vaccine. Different times intervals before symptom onset were considered (90, 180, 365, and 730 days). Vaccine exposure status was determined from Kaiser Immunization Tracking System and supplemented by chart reviews. Risk of association was, moreover, also determined for tetanus and hepatitis B vaccines. | |
Outcomes | ||
Notes | This study was funded by the Centers for Disease Control and Prevention Vaccine Safety Datalink Project. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
CC ‐ case selection All outcomes | Low risk | Included as cases the incident cases from the cohort analysis and additional new onset cases identified from the study population whose symptoms began during 1996. |
CC ‐ control selection All outcomes | Low risk | Same population |
CC ‐ comparability All outcomes | Unclear risk | Poor matching |
CC ‐ exposure All outcomes | Low risk | NCKPHP databases |
Summary assessment | Unclear risk | Unclear |