pba Poehling 2011.
Methods | Case‐control study assessing the effectiveness of influenza vaccine administered during pregnancy in preventing influenza in newborns under 6 months | |
Participants | Children (n = 1510) aged below 6 months who were hospitalised for fever or acute respiratory illness, or both during 7 consecutive epidemic seasons (between 2002 and 2003 and 2008 and 2009). Those with positive laboratory confirmation of influenza were enrolled as cases (n = 151); those whose result was negative were enrolled as controls (n = 1359). | |
Interventions | Influenza vaccination during pregnancy | |
Outcomes | Influenza | |
Notes | This project was supported the Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, and Wachovia Research Fund. 3 authors had received past funding from industry (of these 1 was on the MedImmune Advisory Board and another was a NexBio consultant). Funding source ‐ mixed |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
CC ‐ case selection All outcomes | Low risk | Laboratory confirmed |
CC ‐ control selection All outcomes | Low risk | Infants without laboratory‐confirmed influenza |
CC ‐ comparability All outcomes | Unclear risk | No matching, unclear information |
CC ‐ exposure All outcomes | Unclear risk | Structured interview |
Summary assessment | Unclear risk | Unclear |