1 Quantity of drinking (g/week) at 12 months |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
2 Quantity of drinking (g/week) at 12 months, restricted to trials at low risk of bias due to allocation concealment |
19 |
8856 |
Mean Difference (IV, Random, 95% CI) |
‐19.98 [‐30.45, ‐9.51] |
3 Quantity of drinking (g/week) at 12 months, restricted to trials at low risk of bias due to attrition |
19 |
8496 |
Mean Difference (IV, Random, 95% CI) |
‐20.69 [‐31.78, ‐9.60] |
4 Quantity of drinking (g/week) at 12 months, with imputation of unknown standard deviations |
39 |
17514 |
Mean Difference (IV, Random, 95% CI) |
‐19.35 [‐26.90, ‐11.80] |
5 Quantity of drinking (g/week) at 12 months, subgrouped by cluster/individual randomisation |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
5.1 Cluster‐randomised |
6 |
2588 |
Mean Difference (IV, Random, 95% CI) |
‐25.30 [‐42.69, ‐7.91] |
5.2 Individually randomised |
28 |
12609 |
Mean Difference (IV, Random, 95% CI) |
‐18.77 [‐28.01, ‐9.53] |
6 Quantity of drinking (g/week) at 12 months, subgrouped by cluster/individual randomisation, varying imputed ICC |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐19.41 [‐27.59, ‐11.22] |
6.1 Cluster‐randomised |
6 |
2588 |
Mean Difference (IV, Random, 95% CI) |
‐20.32 [‐33.50, ‐7.14] |
6.2 Individually randomised |
28 |
12609 |
Mean Difference (IV, Random, 95% CI) |
‐18.77 [‐28.01, ‐9.53] |
7 Quantity of drinking (g/week) at 12 months, subgrouped by gender |
11 |
4836 |
Mean Difference (IV, Random, 95% CI) |
‐37.42 [‐54.39, ‐20.45] |
7.1 Men |
11 |
3486 |
Mean Difference (IV, Random, 95% CI) |
‐42.21 [‐64.53, ‐19.89] |
7.2 Women |
7 |
1350 |
Mean Difference (IV, Random, 95% CI) |
‐30.27 [‐58.99, ‐1.55] |
8 Quantity of drinking (g/week) at 12 months, subgrouped by gender, excluding trials of men only |
7 |
4036 |
Mean Difference (IV, Random, 95% CI) |
‐33.12 [‐51.47, ‐14.76] |
8.1 Men |
7 |
2686 |
Mean Difference (IV, Random, 95% CI) |
‐35.16 [‐60.51, ‐9.80] |
8.2 Women |
7 |
1350 |
Mean Difference (IV, Random, 95% CI) |
‐30.27 [‐58.99, ‐1.55] |
9 Quantity of drinking (g/week) at 12 months, subgrouped by adolescents/young adults only versus other |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
9.1 Adolescents/young adults only |
3 |
1638 |
Mean Difference (IV, Random, 95% CI) |
‐7.09 [‐17.18, 2.99] |
9.2 Other trials |
31 |
13559 |
Mean Difference (IV, Random, 95% CI) |
‐22.79 [‐32.42, ‐13.16] |
10 Quantity of drinking (g/week) at 12 months, subgrouped by general practice/emergency setting |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
10.1 General practice setting |
24 |
8811 |
Mean Difference (IV, Random, 95% CI) |
‐25.69 [‐37.30, ‐14.08] |
10.2 Emergency care setting |
10 |
6386 |
Mean Difference (IV, Random, 95% CI) |
‐9.73 [‐17.52, ‐1.93] |
11 Quantity of drinking (g/wk) at 12 months, subgrouped by intervention modality (advice versus counselling) |
32 |
13780 |
Mean Difference (IV, Random, 95% CI) |
‐21.01 [‐30.06, ‐11.96] |
11.1 Advice‐based |
20 |
8243 |
Mean Difference (IV, Random, 95% CI) |
‐32.68 [‐45.75, ‐19.60] |
11.2 Counselling‐based |
12 |
5537 |
Mean Difference (IV, Random, 95% CI) |
‐0.17 [‐2.96, 2.61] |
12 Quantity of drinking (g/week) at 12 months, subgrouped by type of control |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
12.1 No alcohol content |
18 |
8606 |
Mean Difference (IV, Random, 95% CI) |
‐24.41 [‐36.47, ‐12.35] |
12.2 Some alcohol content |
16 |
6591 |
Mean Difference (IV, Random, 95% CI) |
‐12.80 [‐22.93, ‐2.66] |
13 Quantity of drinking (g/week), subgrouped by length of follow‐up |
38 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
13.1 At 6 months |
21 |
10313 |
Mean Difference (IV, Random, 95% CI) |
‐21.56 [‐31.56, ‐11.55] |
13.2 At 8 to 9 months |
2 |
352 |
Mean Difference (IV, Random, 95% CI) |
‐15.70 [‐34.19, 2.79] |
13.3 At 12 months |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
13.4 At 36 months |
1 |
277 |
Mean Difference (IV, Random, 95% CI) |
‐6.11 [‐79.55, 67.33] |
14 Quantity of drinking (g/week), subgrouped by length of follow‐up (6 and 12 months) and restricted to trials with information at both times |
18 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
14.1 At 6 months |
18 |
9739 |
Mean Difference (IV, Random, 95% CI) |
‐21.28 [‐31.82, ‐10.75] |
14.2 At 12 months |
18 |
9645 |
Mean Difference (IV, Random, 95% CI) |
‐22.25 [‐34.04, ‐10.47] |
15 Quantity of drinking (g/week) at 12 months, subgrouped by effectiveness/efficacy |
34 |
15197 |
Mean Difference (IV, Random, 95% CI) |
‐20.08 [‐28.36, ‐11.81] |
15.1 Effectiveness trials |
16 |
7091 |
Mean Difference (IV, Random, 95% CI) |
‐27.06 [‐41.49, ‐12.63] |
15.2 Efficacy trials |
18 |
8106 |
Mean Difference (IV, Random, 95% CI) |
‐14.37 [‐23.97, ‐4.76] |
16 Frequency of binge drinking (number binges/week) at 12 months |
15 |
6946 |
Mean Difference (IV, Random, 95% CI) |
‐0.08 [‐0.14, ‐0.02] |
17 Frequency of drinking (number binges/week), subgrouped by length of follow‐up (6 & 12 months) and restricted to trials with information at both times |
9 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
17.1 At 6 months |
9 |
4354 |
Mean Difference (IV, Random, 95% CI) |
‐0.15 [‐0.22, ‐0.08] |
17.2 At 12 months |
9 |
4333 |
Mean Difference (IV, Random, 95% CI) |
‐0.12 [‐0.23, ‐0.02] |
18 Frequency of drinking (number days drinking/week) at 12 months |
11 |
5469 |
Mean Difference (IV, Random, 95% CI) |
‐0.13 [‐0.23, ‐0.04] |
19 Frequency of drinking (number days drinking/week), subgrouped by length of follow‐up (6 & 12 months) and restricted to trials with information at both times |
6 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
19.1 At 6 months |
6 |
3637 |
Mean Difference (IV, Random, 95% CI) |
‐0.12 [‐0.24, 0.00] |
19.2 At 12 months |
6 |
3658 |
Mean Difference (IV, Random, 95% CI) |
‐0.16 [‐0.28, ‐0.04] |
20 Intensity of drinking (g/drinking day) at 12 months |
10 |
3128 |
Mean Difference (IV, Random, 95% CI) |
‐0.18 [‐3.09, 2.73] |
21 Heavy drinkers at 12 months |
18 |
7623 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.09 [‐0.13, ‐0.04] |
22 Binge drinkers at 12 months |
10 |
4456 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.07 [‐0.12, ‐0.02] |
23 Laboratory markers ‐ GGT (IU/L) at 12 months |
3 |
1166 |
Mean Difference (IV, Random, 95% CI) |
‐0.89 [‐3.86, 2.08] |
24 Laboratory markers ‐ GGT (IU/L) at 12 months, subgrouped by gender |
2 |
1094 |
Mean Difference (IV, Random, 95% CI) |
‐0.03 [‐2.52, 2.46] |
24.1 Men |
2 |
764 |
Mean Difference (IV, Random, 95% CI) |
‐2.08 [‐6.10, 1.95] |
24.2 Women |
2 |
330 |
Mean Difference (IV, Random, 95% CI) |
1.23 [‐1.94, 4.40] |