Tofigh 2007.

Methods	Site: AK Study design: RCT Method of randomisation: unclear Blinding: unblinded, intention to treat Exclusions post randomisation: none Losses to follow up: 6 (6%)
Participants	Country: France Setting: hospital No. of participants: 85 (103 limbs; 51 reversed vein, 52 polyester) Age (median): 69 yrs Sex: 49 males, 36 females Inclusion criteria: severe claudication, rest pain, tissue loss Exclusion criteria: patients with earlier bypass or un‐useable LSV
Interventions	6 mm collagen‐impregnated woven polyester prosthesis and reversed vein graft Oral warfarin from one day pre‐op continued for 6 months. 38 mg aspirin afterwards
Outcomes	Primary and secondary patency 5‐year follow‐up
Notes	No medication compliance checks. Unclear randomisation
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No description of randomisation technique
Allocation concealment (selection bias)	Unclear risk	No clear description
Blinding of participants and personnel (performance bias) All outcomes	High risk	Operative blinding impossible in this type of trial
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Outcome assessors and patients not obviously blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses, clear data
Selective reporting (reporting bias)	Low risk	All stated outcomes reported
Other bias	Low risk	No obvious other source of bias