Table 2:
Top 20 significantly perturbed (enhanced) “GO Biological Function” pathways following miR-181a/b-1 over-expression at day 7 of osteogenic induction.
| Pathway | Mean Linear FC |
P-Value |
|---|---|---|
| Translational termination (GO:0006415) | 25.79 | 2.27e-06 |
| Translational elongation (GO:0006414) | 23.92 | 3.48e-06 |
| Translational initiation (GO:0006413) | 20.93 | 7.52e-06 |
| Mitochondrial translational initiation (GO:0070124) | 17.77 | 3.25e-05 |
| Cellular respiration (GO:0045047) | 17.63 | 2.38e-05 |
| Mitochondrial translation (GO:0032543) | 16.86 | 3.65e-05 |
| Mitochondrial translational elongation (GO:0070124) | 16.86 | 4.31e-05 |
| Respiratory electron transport chain (GO:0022904 | 16.77 | 3.78e-05 |
| Mitochondrial translational termination (GO:0070126) | 14.95 | 8.00e-05 |
| Cellular protein complex disassembly (GO:0043624) | 14.37 | 7.02e-05 |
| Electron transport chain (GO:0022900) | 13.05 | 1.41e-04 |
| Protein complex disassembly (GO:0043241) | 12.57 | 1.47e-04 |
| Macromolecular complex disassembly (GO:0032984) | 12.27 | 1.66e-04 |
| Cotranslational protein targeting to membrane (GO:0006613) | 11.38 | 2.97e-04 |
| Generation of precursor metabolites and energy (GO:0006091) | 11.02 | 2.87e-04 |
| Protein folding (GO:0006457) | 10.77 | 3.49e-04 |
| SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 10.65 | 4.14e-04 |
| Glycosyl compound metabolic process (GO: 1901657) | 10.58 | 3.59e-04 |
| Energy derivation by oxidation of organic compounds (GO:0015980) | 10.46 | 3.81e-04 |
| Protein localization to endoplasmic reticulum (GO:0070972) | 10.31 | 4.63e-04 |