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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Heart Rhythm. 2018 Nov 7;16(5):765–772. doi: 10.1016/j.hrthm.2018.11.001

Figure 5. Increased CaMKII activity leads to higher Ca2+ spark frequency in HIP rat hearts.

Figure 5.

(A) CaMKII activity in hearts from WT and HIP rats. N=4 hearts/group. (B) Representative immunoblots for oxidized and total CaMKII in HIP and WT hearts and the relative amount of oxidized CaMKII. N=6 hearts/group and immunoblots were repeated 5 times. (C) Change in Ca2+ spark frequency produced by CaMKII inhibitors KN-93 and myristoylated-AIP (both 1 μM). Data were collected from 4–6 HIP and 4–6 WT rats (4–8 myocytes/rat). Spark frequency was first averaged over the cells from the same rat and the mean spark frequency per rat was averaged for each group.