Comparison 1. Lorazepam versus diazepam.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Seizure cessation	3	439	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.98, 1.20]
1.1 Intravenous	3	414	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.94, 1.16]
1.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	2.86 [1.47, 5.55]
2 Time from drug administration to stopping of seizures	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Intravenous	1	80	Mean Difference (IV, Fixed, 95% CI)	6.18 [‐7.83, 20.19]
3 Incidence of respiratory depression	3	439	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.55, 0.93]
3.1 Intravenous	3	414	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.55, 0.92]
3.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.04, 20.78]
4 Additional dose of the trial drug required to stop seizures	3	439	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.64, 1.20]
4.1 Intravenous	3	414	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.71, 1.33]
4.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.56]
5 Additional drugs required to stop seizures	2	359	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.45, 1.24]
5.1 Intravenous	2	334	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.54, 1.55]
5.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.69]
6 Seizure recurrence within 24 hours	3	439	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.61, 1.20]
6.1 Intravenous	3	414	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.65, 1.27]
6.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 2.92]
7 Incidence of admissions to the intensive care unit (ICU)	1	86	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.02, 0.98]
7.1 Intravenous	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	0.07 [0.00, 1.22]
7.2 Rectal	1	25	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.03, 10.51]