Comparison 9. Intramuscular midazolam versus intravenous diazepam.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Seizure cessation	2	105	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.87, 1.09]
2 Time from drug administration to stopping of seizures (minutes)	2		Mean Difference (Fixed, 95% CI)	Subtotals only
2.1 Treatment initiation time (minutes)	1	24	Mean Difference (Fixed, 95% CI)	‐4.5 [‐6.68, ‐2.32]
2.2 Time for drug effect (minutes)	1	24	Mean Difference (Fixed, 95% CI)	1.1 [‐0.91, 3.11]
2.3 Total time to seizure cessation (minutes)	2	105	Mean Difference (Fixed, 95% CI)	‐2.68 [‐3.94, ‐1.42]
3 Additional drugs required to stop seizures	2	105	Risk Ratio (M‐H, Fixed, 95% CI)	1.34 [0.35, 5.13]
4 Seizure recurrence within 24 hours	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Within 15 minutes	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.06, 12.01]
4.2 Within one hour	1	24	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.27, 2.62]