Comparison 1.

Glucocorticosteroids versus no intervention/placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	15		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Up to 3 months after randomisation	15	1861	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.70, 1.15]
1.2 At the end of treatment	14	1824	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.66, 1.15]
1.3 At 1 year after randomisation	3	1343	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.91, 1.17]
2 Health‐related quality of life	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2.1 Up to three months	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Up to one year	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
3 Number of participants with serious adverse events during treatment	15	1861	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.85, 1.29]
4 Liver‐related mortality	15	1861	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.69, 1.14]
4.1 Up to 3 months' follow‐up after randomisation	15	1861	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.69, 1.14]
5 Any complication	15	1861	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.86, 1.27]
5.1 Number of participants with complications up to 3 months' follow‐up after randomisation	15	1861	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.86, 1.27]
6 Number of participants with non‐serious adverse events up to 3 months' follow‐up after randomisation	4	160	Risk Ratio (M‐H, Fixed, 95% CI)	1.99 [0.72, 5.48]