Richardet 1993

Methods	A randomised clinical trial with a cross‐over design Intention to‐treat analysis: not mentioned Sample size calculation was not reported
Participants	Demographic characteristics: no information. Inclusion criteria and degree of severity: non‐infected patients with histologically proven alcoholic hepatitis. All patients had severe hepatic failure (prothrombin time < 50%, or bilirubin > 5.6 mg/dL, or encephalopathy) Number of participants randomised: 23 Glucocorticosteroid group: 12 participants Placebo group: 11 participants
Interventions	Prednisolone group: prednisolone 40 mg daily Control group: placebo 40 mg daily Duration of treatment: Prednisolone group: 1 week of treatment followed by one week of no treatment Control group: 1 week of no treatment followed by one week of treatment After that, both groups received glucocorticosteroids for three weeks. Duration of follow‐up: at discharge from hospital (three months)
Outcomes	The trial outcomes were: Mortality Liver biochemistry
Notes	Country: France. Letter sent to study authors in 2006. No answer received. Only published as abstract
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No information
Selective reporting (reporting bias)	Unclear risk	No information
For‐profit bias	Unclear risk	Not reported
Other bias	Unclear risk	No information