Comparison 2. Vitamin K dosage.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Bleeding complications	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 0.2 mg IM versus 0.5 mg IM	1	54	Risk Ratio (M‐H, Fixed, 95% CI)	0.12 [0.01, 2.11]
2 Intraventricular hemorrhage > Grade II	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 0.2 mg IM versus 0.5 mg IM	1	54	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.04, 3.24]
3 Presence of PIVKA II at day 5	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 0.2 mg IM versus 0.5 mg IM	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [0.24, 7.57]
4 Presence of PIVKA II at day 25	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 0.2 mg IM versus 0.5 mg IM	1	53	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.06, 14.60]
5 Prolonged PT at day 5	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 0.2 mg IM versus 0.5 mg IM	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [0.53, 3.93]
6 Vitamin K1 epoxide detected (≥ 10 ng/mL on day 5)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 0.2 mg IM versus 0.5 mg IM	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	0.06 [0.00, 1.02]
7 Vitamin K1 epoxide detected (≥ 0.3 ng/mL on day 25)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 0.2 mg IM versus 0.5 mg IM	1	54	Risk Ratio (M‐H, Fixed, 95% CI)	0.27 [0.03, 2.25]
8 Necrotizing enterocolitis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 0.2 mg IM versus 0.5 mg IM	1	54	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.16, 7.10]
9 Sepsis	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
9.1 0.2 mg IM versus 0.5 mg IM	1	54	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.26, 2.86]
10 Mortality (all infants)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
10.1 0.2 mg IM versus 0.5 mg IM	1	65	Risk Ratio (M‐H, Fixed, 95% CI)	2.13 [0.60, 7.51]