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. 2018 Jan 29;2018(1):CD011292. doi: 10.1002/14651858.CD011292.pub2

Comparison 4. Comparison: fatigue and vigour, all physical activity vs control.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Overall fatigue (follow‐up values) 26   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.1 End of intervention 26 2020 Std. Mean Difference (IV, Random, 95% CI) ‐0.32 [‐0.47, ‐0.18]
1.2 Follow‐up 7 536 Std. Mean Difference (IV, Random, 95% CI) ‐0.43 [‐0.60, ‐0.26]
2 Overall fatigue (change values) 13   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
2.1 End of intervention 13 1289 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.61, 0.00]
2.2 Follow‐up 4 178 Std. Mean Difference (IV, Random, 95% CI) ‐0.47 [‐0.84, ‐0.11]
3 FACT‐Fatigue (follow‐up values) 7   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 End of intervention 7 952 Mean Difference (IV, Fixed, 95% CI) 1.14 [‐0.06, 2.35]
3.2 Follow‐up 2 112 Mean Difference (IV, Fixed, 95% CI) 1.49 [‐1.95, 4.93]
4 FACT‐Fatigue (change values) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
4.1 End of intervention 4 925 Mean Difference (IV, Random, 95% CI) ‐0.54 [‐3.23, 2.14]
4.2 Follow‐up 1 36 Mean Difference (IV, Random, 95% CI) 1.28 [‐4.11, 6.67]
5 EORTC QLQ‐C30 Fatigue scale (follow‐up values) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 End of intervention 2 119 Mean Difference (IV, Fixed, 95% CI) ‐6.83 [‐13.08, ‐0.58]
5.2 Follow‐up 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 EORTC QLQ‐C30 Fatigue scale (change values) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
6.1 End of intervention 2 73 Mean Difference (IV, Random, 95% CI) ‐2.81 [‐14.98, 9.36]
6.2 Follow‐up 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Multidimensional Fatigue Symptom Inventory (follow‐up values) 5   Mean Difference (IV, Random, 95% CI) Subtotals only
7.1 End of intervention 5 366 Mean Difference (IV, Random, 95% CI) ‐0.53 [‐1.35, 0.29]
7.2 Follow‐up 3 304 Mean Difference (IV, Random, 95% CI) ‐2.04 [‐4.30, 0.23]
8 Multidimensional Fatigue Symptom Inventory ‐ interference (follow‐up values) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
8.1 End of intervention 2 62 Mean Difference (IV, Random, 95% CI) ‐0.37 [‐1.34, 0.60]
8.2 Follow‐up 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Revised Piper Fatigue Scale total fatigue (follow‐up values) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
9.1 End of intervention 4 187 Mean Difference (IV, Random, 95% CI) ‐1.18 [‐2.38, 0.02]
9.2 Follow‐up 2 120 Mean Difference (IV, Random, 95% CI) ‐1.15 [‐1.86, ‐0.43]
10 Revised Piper Fatigue Scale total fatigue (change values) 4   Mean Difference (IV, Random, 95% CI) Subtotals only
10.1 End of intervention 4 166 Mean Difference (IV, Random, 95% CI) ‐1.96 [‐2.93, 1.00]
10.2 Follow‐up 2 120 Mean Difference (IV, Random, 95% CI) ‐1.14 [‐1.78, ‐0.49]
11 Revised Piper Fatigue Scale behavioural/severity (follow‐up values) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
11.1 End of intervention 3 121 Mean Difference (IV, Random, 95% CI) ‐1.24 [‐2.49, 0.01]
11.2 Follow‐up 1 61 Mean Difference (IV, Random, 95% CI) ‐1.41 [‐2.57, ‐0.25]
12 Revised Piper Fatigue Scale affective/meaning (follow‐up values) 3   Mean Difference (IV, Fixed, 95% CI) Subtotals only
12.1 End of intervention 3 121 Mean Difference (IV, Fixed, 95% CI) ‐2.11 [‐3.03, ‐1.20]
12.2 Follow‐up 1 61 Mean Difference (IV, Fixed, 95% CI) ‐2.05 [‐3.21, ‐0.89]
13 Revised Piper Fatigue Scale sensory (follow‐up values) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
13.1 End of intervention 3 121 Mean Difference (IV, Random, 95% CI) ‐0.44 [‐3.11, 2.22]
13.2 Follow‐up 1 61 Mean Difference (IV, Random, 95% CI) ‐1.60 [‐2.65, ‐0.55]
14 Revised Piper Fatigue Scale cognitive/mood (follow‐up values) 3   Mean Difference (IV, Random, 95% CI) Subtotals only
14.1 End of intervention 3 121 Mean Difference (IV, Random, 95% CI) ‐0.72 [‐2.31, 0.87]
14.2 Follow‐up 1 61 Mean Difference (IV, Random, 95% CI) ‐1.40 [‐2.50, ‐0.30]
15 Schwartz Cancer Fatigue Scale (follow‐up values) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
15.1 End of intervention 2 125 Mean Difference (IV, Random, 95% CI) ‐2.01 [‐9.25, 5.23]
15.2 Follow‐up 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 POMS fatigue scale (follow‐up values) 2   Std. Mean Difference (IV, Fixed, 95% CI) Subtotals only
16.1 End of intervention 2 79 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.54 [1.00, ‐0.08]
16.2 Follow‐up 1 61 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.57 [‐1.08, ‐0.05]
17 Visual analogue scale fatigue (follow‐up and change values) 4   Std. Mean Difference (IV, Fixed, 95% CI) Subtotals only
17.1 End of intervention 4 148 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.51 [‐0.88, ‐0.14]
17.2 Follow‐up 1 22 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
18 Overall vigour/vitality (follow‐up values) 10   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
18.1 End of intervention 10 762 Std. Mean Difference (IV, Random, 95% CI) 0.36 [0.21, 0.50]
18.2 Follow‐up 4 454 Std. Mean Difference (IV, Random, 95% CI) 0.26 [0.04, 0.48]
19 Overall vigour/vitality (change values) 6   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
19.1 End of intervention 6 359 Std. Mean Difference (IV, Random, 95% CI) 0.23 [0.00, 0.45]
19.2 Follow‐up 2 233 Std. Mean Difference (IV, Random, 95% CI) 0.20 [‐0.06, 0.46]
20 MOS SF vitality (follow‐up values) 6   Mean Difference (IV, Fixed, 95% CI) Subtotals only
20.1 End of intervention 6 514 Mean Difference (IV, Fixed, 95% CI) 3.08 [0.84, 5.31]
20.2 Follow‐up 2 306 Mean Difference (IV, Fixed, 95% CI) 5.09 [0.99, 9.19]
21 MOS SF vitality (change values) 4   Mean Difference (IV, Fixed, 95% CI) Subtotals only
21.1 End of intervention 4 212 Mean Difference (IV, Fixed, 95% CI) 1.36 [‐0.52, 3.25]
21.2 Follow‐up 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 POMS vigour scale (follow‐up values) 4   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
22.1 End of intervention 4 248 Std. Mean Difference (IV, Random, 95% CI) 0.46 [0.13, 0.79]
22.2 Follow‐up 2 148 Std. Mean Difference (IV, Random, 95% CI) 0.21 [‐0.34, 0.77]
23 POMS vigour scale (change values) 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
23.1 End of intervention 2 147 Std. Mean Difference (IV, Random, 95% CI) 0.25 [‐0.45, 0.95]
23.2 Follow‐up 2 233 Std. Mean Difference (IV, Random, 95% CI) 0.20 [‐0.06, 0.46]