Holsinger 2012.

Study characteristics
Patient sampling	Random sample of primary care patients without known history of dementia. Patients, ≥ 65 years were randomly sampled from electronic medical records of 3 Department of Veterans Affairs primary care clinics close to Durham, N.C., USA. Participants were required to have at least 1 primary care visit in the preceding 18 months.
Patient characteristics and setting	Excluded individuals with chart diagnosis of dementia or psychotic illness. The remaining population of individuals > 65 years were randomly selected. All potentially eligible female participants were selected due to the small numbers of women in the primary care locations. Patients with severe visual and hearing impairment, unable to recall an informant for supplemental cognitive history, active alcohol or drug abuse, unstable medical conditions and insufficient English fluency were excluded from the study. Number of participants: dementia: 21, no dementia: 362 Participant mean age (SD): dementia: 79.0 (5.1), no dementia: 74.2 (6.5) Female gender number (%): dementia: 1 (4.8%), no dementia: 30 (8.3%) Years of education (SD): dementia: 11.1 (3.9), no dementia: 13.5 (3.2)
Index tests	Mini‐Cog scored with original scoring algorithm, as per Borson 2000
Target condition and reference standard(s)	Diagnosis of dementia based on the criteria of DSM‐IV‐TR, NINDS‐ADRDA, NINCDS‐AIREN. Evaluated by a consensus panel of specialists from neurology, internal medicine, geriatric psychiatry and cognitive neuroscience. Evaluations were based on clinical interview, history by informant, neuropsychological testing, standardized neurology exam and review of the electronic medical record.
Flow and timing	Data were not available for 9/639 patients selected. 1242 patients were contacted, patients with a variable informant, who matched the eligibility guidelines and showed up for the evaluation totaled 639.
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
		Low	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Yes
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Yes
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low