Lipidomic analysis comparing TCs before the loss of HIV-1 control and PCs. Random Forest analysis showed lipid levels by importance of classification (A). Principal Component Analysis (PCA) showing that lipids with a mean decrease in accuracy higher than 50 allowed a great differentiation between the studied groups (B). Transient controllers (TCs, blue, n = 8) and persistent controllers, (PCs, red, n = 8). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)