Table 1.
Strains | Sampling date | Sex of patients | Age of patients | Serotypes | MIC of polymyxin B | Phenotype Resistance to third and fourth-generation cephalosporinsa | Phenotype Resistance to ciprofloxacinb | Levels of antibiotic resistancec | Strategies of sequencing | Replicon sequence type of mcr-1-positive plasmids |
---|---|---|---|---|---|---|---|---|---|---|
SH12G402 | 2012/6/7 | female | 1 year | Enterica | 8 | CAZ, CTX, FEP | R | MDR | PacBio RSII | IncI2 |
SH12G950 | 2012/7/28 | male | 10 months | Typhimurium | 8 | CTX | R | MDR | MinION+HiSeq | IncI2 |
SH13G1582 | 2013/7/31 | male | 2 years | Wandsworth | 8 | CTX | R | MDR | PacBio RSII | IncI2 |
SH13G841 | 2013/10/20 | male | 9 months | Typhimurium | 8 | CAZ, CTX, FEP | S | MDR | HiSeq+Sanger | IncI2 |
SH14G1670 | 2014/6/1 | female | 2 years | Typhimurium | 4 | CTX, FEP | R | XDR | PacBio RSII | IncHI2 |
SH15G1169 | 2015/8/26 | male | 34 years | Typhimurium | 8 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH15G1219 | 2015/9/7 | male | 1 year | Typhimurium | 4 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH15G1397 | 2015/12/10 | male | 8 years | Typhimurium | 4 | CAZ, CTX, FEP | S | XDR | MinION+HiSeq | IncX4 |
SH15G1428 | 2015/9/7 | female | 1 year | Typhimurium | 8 | CTX, FEP | R | XDR | MinION+HiSeq | IncHI2 |
SH15G1450 | 2015/9/7 | female | 3 years | Typhimurium | 8 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH15G1452 | 2015/10/13 | male | 1 year | Typhimurium | 4 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH15G1493 | 2015/9/28 | male | 4 years | Typhimurium | 8 | CAZ, CTX | R | MDR | MinION+HiSeq | IncI2 |
SH15G1527 | 2015/10/19 | male | 10 months | Typhimurium | 8 | S | S | MDR | PacBio RSII | IncI2 |
SH15G1531 | 2015/10/27 | male | 8 months | Typhimurium | 8 | S | S | MDR | HiSeq+sanger | IncI2 |
SH15G1571 | 2015/11/14 | female | 10 months | Typhimurium | 8 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH15G1598 | 2015/12/28 | female | 2 years | Typhimurium | 8 | S | R | MDR | MinION+HiSeq | IncHI2 |
SH15G2167 | 2015/7/15 | female | 9 months | Typhimurium | 8 | S | R | MDR | MinION+HiSeq | IncX4 |
SH15G2169 | 2015/7/15 | male | 2 years | Typhimurium | 8 | S | R | MDR | MinION+HiSeq | IncX4 |
SH15G2194 | 2015/10/28 | female | 1 year | Typhimurium | 4 | CAZ, CTX | R | XDR | MinION+HiSeq | IncHI2 |
SH16G0600 | 2016/5/10 | male | 3 months | Typhimurium | 4 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G0612 | 2016/6/12 | male | 9 months | Typhimurium | 8 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G0648 | 2016/6/17 | male | 1 year | Typhimurium | 4 | CTX | S | MDR | MinION+HiSeq | IncHI2 |
SH16G1369 | 2016/6/26 | female | 32 years | Typhimurium | 4 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G1394 | 2016/8/1 | female | 2 years | Typhimurium | 4 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G1508 | 2016/7/18 | male | 8 months | Typhimurium | 8 | S | S | MDR | MinION+HiSeq | IncHI2 |
SH16G1509 | 2016/8/16 | male | 8 years | Typhimurium | 8 | CTX, FEP | S | MDR | MinION+HiSeq | IncX4 |
SH16G2456 | 2016/6/19 | male | 1 year | Typhimurium | 4 | CTX, FEP | R | XDR | MinION+HiSeq | IncHI2 |
SH16G2457 | 2016/8/17 | female | 1 year | Typhimurium | 4 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH16G2543 | 2016/8/14 | male | 2 years | Typhimurium | 4 | S | S | MDR | MinION+HiSeq | IncX4 |
SH16G4466 | 2016/6/21 | female | 9 months | Typhimurium | 4 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G4498 | 2016/8/23 | male | 10 months | Typhimurium | 4 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH16G4511 | 2016/7/4 | male | 1 year | Typhimurium | 8 | CTX, FEP | S | XDR | MinION+HiSeq | IncHI2 |
SH16G4525 | 2016/8/25 | male | 1 year | Typhimurium | 8 | CTX, FEP | R | MDR | MinION+HiSeq | IncHI2 |
SH16G4909 | 2016/8/10 | male | 3 years | Typhimurium | 8 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G4918 | 2016/8/16 | female | 9 months | Typhimurium | 4 | CTX, FEP | S | MDR | MinION+HiSeq | IncHI2 |
SH16G4926 | 2016/8/27 | male | 7 months | Typhimurium | 8 | CTX, FEP | S | XDR | MinION+HiSeq | IncHI2 |
SH16G4928 | 2016/8/31 | male | 1 year | Typhimurium | 4 | CTX | S | MDR | MinION+HiSeq | IncI2 |
Resistance to the third- and fourth-generation cephalosporins, including ceftazidime (CAZ), cefotaxime (CTX), or cefepime (FEP), in the antimicrobial susceptibility testing.
R: resistance to ciprofloxacin; S: sensitivity to ciprofloxacin.
MDR: multidrug-resistant strains, defined as resistant to more than three kinds of antibiotics; XDR: extensively drug-resistant strains, defined as sensitive to less than three kinds of antibiotics.