Table 3.

Severity of diarrhea by grade according to the NCI CTC for Adverse Events (NCI-CTCAE v4) [27]

Grade	Description
1 (Mild)	Increase of < 4 stools per day over baseline; mild increase in ostomy output compared to baseline
2 (Moderate)	Increase of 4 to 6 stools per day over baseline; moderate increase in ostomy output compared to baseline
3 (Severe)	Increase of ≥ 7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self-care ADL
4 (Life-threatening)	Life-threatening consequences; urgent intervention indicated
5 (Death)	Death

ADL activities of daily living, AE adverse event, CTC Common Toxicity Criteria, NCI National Cancer Institute