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. 2019 Apr 3;42:225–237. doi: 10.1016/j.ebiom.2019.03.040

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Effects of JWH133 on excitatory synaptic transmission in VTA DA neurons. (a) Typical traces of mEPSCs in the presence of TTX (1 μM) and picrotoxin (100 μM) before (top trace) and after (bottom trace) JWH133 (10 μM) exposure using whole-cell patch-clamp recording in a VTA slice. In 19 slices, cumulative probability analysis for mEPSC inter-event interval (b) and amplitude (c) under control conditions (black curve) and JWH133 exposure (red curve). (d) Comparison of mEPSC frequency (left panel) and amplitude (right panel) before and after JWH133 exposure from 19 VTA slices tested. (e) Bar graph data illustrating JWH133 significantly reduced mEPSC frequency, but not amplitude. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)