Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 30;9:6663. doi: 10.1038/s41598-019-43248-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Gene set enrichment analysis (GSEA) reveals the distinct modulation of transcriptional regulators. The enrichment of transcriptional regulators in the transcriptomic response of mouse livers exposed to corn oil or PCN (50 mg/kg/day) for 3 days followed by saline or LPS (2 mg/kg) for 16 h was assessed using GSEA. An extensive search was carried out for transcriptional regulators that were enriched (FDR-adjusted Q-value < 0.25) but with targets changed in the opposite direction between the PCN and LPS treatments compared to those in the control. We report transcriptional regulators with a positive NES (acting primarily as transcriptional activators for Cyp3a11) and those with a negative NES (acting primarily as transcriptional repressors for Cyp3a11).