Table 1.
Top 15 differentially regulated genes (represented by their gene symbols) by PCN, LPS and combined PCN/LPS treatments compared to those in the control.
| PCN vs Control | LPS vs Control | PCN/LPS vs Control | PCN/LPS vs PCN/Sal | PCN/LPS vs CO/LPS | |||||
|---|---|---|---|---|---|---|---|---|---|
| Up | Down | Up | Down | Up | Down | Up | Down | Up | Down |
| GSTA1 | CYP4A14 | REG3B | CAR3 | S100A8 | HSD3B5 | CXCL9 | THRSP | CYP3A11 | CYP4A14 |
| GSTM3 | CML2 | S100A8 | HSD3B5 | S100A9 | HAMP2 | SAA3 | CAR3 | CES6 | FDPS |
| CYP2C55 | EGFR | S100A9 | CPS1 | SAA3 | CAR3 | S100A9 | AQP8 | GSTA1 | IDI1 |
| CES6 | EGR1 | SAA3 | THRSP | REG3B | AQP8 | S100A8 | HAMP2 | CYP3A25 | REG3A |
| GSTA2 | ARRDC3 | CXCL9 | HAMP2 | CRYBB3 | THRSP | REG3B | HSD3B5 | GSTM3 | SC4MOL |
| CYP2B10 | IDB2 | CRYBB3 | ELOVL3 | CXCL9 | VSIG4 | CRYBB3 | ELOVL6 | GSTA2 | SLC25A25 |
| AKR1B7 | CYP2C67 | CXCL1 | VSIG4 | CXCL1 | ELOVL3 | CD14 | GSTA1 | POR | CYP51 |
| CYP3A11 | GNAT1 | CD14 | INMT | CD14 | CPS1 | CXCL1 | CYP2C55 | HSD17B6 | PPP1R3C |
| GSTM6 | G0S2 | LCN2 | ACSS2 | LCN2 | ACSS2 | CCL5 | G6PC | CYP2C55 | LSS |
| GSTM2 | RNASE4 | ADH7 | AQP8 | MT2 | G6PC | LCN2 | ACSS2 | AKR1B7 | CRELD2 |
| HSD17B6 | ACOT1 | MT2 | CLEC4G | SAA2 | CLEC4G | SAA2 | GSTM3 | CYP2B10 | |
| CYP2B23 | AOX3 | CPNE8 | CYP2A5 | CHI3L3 | SLC2A2 | MT2 | SLC2A2 | GSTM2 | |
| DDIT4 | CYP2C70 | MT1 | UPP2 | CES6 | ACAA1B | CYP17A1 | CHRNA4 | SLCO1A4 | |
| CYP3A25 | HSD3B | SAA2 | G6PC | ADH7 | NUDT7 | GBP2 | CPS1 | GSTM6 | |
| CSAD | MUG2 | STEAP4 | GSTM6 | MT1 | AOX3 | CHI3L3 | GSTM6 | CES3 | |