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. 2019 Apr 30;9:6642. doi: 10.1038/s41598-019-43187-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted secondary structures of cloned aptamers. Some of the aptamers obtained against T_H1N1 and T_H3N2 were analyzed with Mfold, a secondary structure-computing program. (a₁–a₄) For the aptamers selected against T_H1N1 (namely, Apt01 > T_H1N1, Apt02 > T_H1N1, Apt03 > T_H1N1, Apt04 > T_H1N1). (b₁,b₂) For the aptamers Apt01 > T_H3N2 and Apto2 > T_H3N2. Commonly appearing sequences in loop regions are highlighted for the aptamers against T_H1N1 (incidentally, no such sequences were found in the aptamers obtained against T_H3N2). Note that the sequence regions of 1–20 and 51–70 over the entire sequence (70 nucleotides) are primer-binding sites, and they are constant.