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MGO-derived AGE accumulates predominantly in astrocytes. Staining of MGO-derived AGE (red, TRITC) combined with GFAP (green, FITC) (A), Iba1 (green, FITC) (B), and neurofilament (FITC) (C) show that MGO-derived AGE accumulates in astrocytes in normal appearing white matter and lesions of MS patients as indicated by the white arrows. Nuclei were stained with DAPI (blue). Representative of n = 4 staining.
