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. 2019 Apr 24;9:124. doi: 10.3389/fcimb.2019.00124

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Copyright © 2019 Auger, Boa, Segura and Gottschalk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Presence of antigen I/II (AgI/II) promotes S. suis serotype 9 resistance to phagocytosis by resident peritoneal macrophages but not intracellular survival. (A) Phagocytosis of the S. suis serotype 9 wild-type, AgI/II-deficient mutant (ΔagI/II) or complemented (CΔagI/II) strains pre-opsonized with either 20% complete or heat-inactivated normal mouse serum by resident peritoneal macrophages following 1 h of infection. (B) Intracellular survival kinetics of the wild-type, ΔagI/II, and CΔagI/II strains pre-opsonized with 20% complete normal mouse serum within resident peritoneal macrophages following antibiotic treatment. Data represent the mean ± SEM (n = 4). *p < 0.01 indicates a significant difference between the wild-type strain and ΔagI/II mutant.