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. 2019 Apr 30;9:6693. doi: 10.1038/s41598-019-42328-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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knockdown FHL2 prevents angiotensin II-induced Rac1 activation and cytoskeleton rearrangement in podocytes in vitro. Panel a: A representative western blot of FHL2, active- and total Rac1 expression after angiotensin II treatment in cultured podocytes. Panel b: Quantification of FHL2 expression (n = 3). Panel c: Quantification of active-Rac1 (n = 3). Panel d: Representative figures of podocytes lamellipodium formation and migration. Panel e: Quantification of migrated podocyte number (n = 3). Panel f: Co-immunoprecipitation (Co-IP) confirmed FHL2 and FAK has structural protein-protein interaction in podocytes. *p < 0.05, **p < 0.01 compared to control.