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Effect of loganin on sleep onset of mice induced by subhypnotic dosage of pentobarbital.
| Groups | Dosage (mg/kg, i.g.) | No. of falling asleep/total | Sleep onset (%) |
|---|---|---|---|
| Vehicle | – | 1/25 | 4.0 |
| Estazolam | 0.15 | 25/25 | 100.0∗ |
| Loganin | 5 | 9/25 | 36.0∗ |
| 20 | 15/25 | 60.0∗ | |
| 50 | 15/25 | 60.0∗ |
Twenty five minutes after administration of distilled water, estazolam, and loganin; pentobarbital (23 mg/kg, i.p.) was given to mice. The number of mice falling asleep was recorded (n = 12), ∗P < 0.05, vs. vehicle (χ2 test).
