Table 2.

Effect of loganin combined with 5-HTP on sleep onset of mice treated with hypnotic dosage of pentobarbital (45 mg/kg, i.p.).

Groups	Dosage (mg/kg)	No. of falling asleep/total	Sleep onset (%)
Vehicle	–	0/12	0.0
5-HTP	2.5 (i.p.)	2/12	16.7∗
Loganin	5 (i.g.)	2/12	16.7∗
5-HTP + Loganin	2.5 (i.p.) +5 (i.g.)	12/12	91.67∗∗

The number of mice falling asleep was recorded (n = 12). ^∗∗P < 0.01, vs. vehicle (χ² test). ^∗P < 0.05, vs. 2.5 mg/kg 5-HTP + 2.5 mg/kg loganin (χ² test).