Table 3.
The concentrations of NE, 5-HT, DA, and their metabolites in the hippocampus, prefrontal cortex and striatum after loganin treatment.
| Group | NE (ng/g) | 5-HT (ng/g) | 5-HIAA (ng/g) | DA (ng/g) | DOPAC (ng/g) | 5-HIAA/5-HT | DOPAC/DA | |
|---|---|---|---|---|---|---|---|---|
| PFC | Control | 673.5 ± 119.1 | 1115 ± 151.4 | 337.5 ± 49.21 | 1031 ± 698.4 | 417.3 ± 145.4 | 0.29 ± 0.02 | 0.58 ± 0.18 |
| Loganin | 469.5 ± 72.33 | 687.7 ± 91.16∗ | 241.3 ± 40.44 | 223.8 ± 56.61∗∗ | 124.7 ± 8.557∗∗ | 0.35 ± 0.05∗ | 0.63 ± 0.071 | |
| STR | Control | 263 ± 64.29 | 466.8 ± 99.63 | 322.1 ± 73.21 | 16052 ± 3693 | 1088 ± 190.4 | 0.78 ± 0.14 | 0.09 ± 0.005 |
| Loganin | 265.6 ± 26.61 | 723 ± 80.8 | 605.2 ± 92.07∗ | 15287 ± 1645 | 1284 ± 125.5 | 0.80 ± 0.07 | 0.09 ± 0.003 | |
| HIP | Control | 478.4 ± 78.22 | 445.6 ± 61.47 | 346.8 ± 84.66 | 66.42 ± 16.19 | ND | 0.60 ± 0.10 | ND |
| Loganin | 515.9 ± 68.09 | 499.3 ± 62.03 | 382.7 ± 98.16 | 75.44 ± 29.22 | ND | 0.59 ± 0.11 | ND |
Data are presented as means ± SEM (n = 9). ∗P < 0.05, ∗∗P < 0.01, vs. control (unpaired Student’s t-test); ND: not detectable.