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. 2019 Apr 24;13:329. doi: 10.3389/fnins.2019.00329

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Copyright © 2019 Gaudioso, Garcia-Rozas, Casarejos, Pastor and Rodriguez-Navarro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PE levels change in PK-KO mice’s mitochondria due to PSD. (A) Levels of phospholipids (PC, PE, PS, LPC, LPE, PG, and PI) and changes due to aging and parkin loss. (B) Levels of phospholipids (PC, PE, and PS) containing arachidonic (20:4) or docosahexaenoic acid (22:6) as lateral chains. (C) Western-blot experiment showing PSD levels in brain’s mitochondria from WT and PK-KO mice. (D) Quantification of PSD intensity in brain’s mitochondria. Graphs represent the mean ± SEM. One Way ANOVA statistical analysis was performed. ^∗p < 0.05 due to aging. ^#p < 0.05 due to parkin loss. n = 4 for lipidomic analysis and n = 6 for western-blot experiments.