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. 2019 Apr 24;13:329. doi: 10.3389/fnins.2019.00329

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Copyright © 2019 Gaudioso, Garcia-Rozas, Casarejos, Pastor and Rodriguez-Navarro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sphingolipids content in PK-KO mice’s brain mitochondria. PK-KO mice’s mitochondria have higher levels of hydroxylated ceramides due to aging. (A) Levels of different classes of sphingolipids (SM, dhCer, Cer, and HexCer) and changes due to aging and parkin loss. (B) Percentage of Hydroxylated ceramide species. (C) Percentage of Hydroxylated Hexosyl Ceramide species. (D) Percentage of ceramide species. (E) Percentage of HexCer species. For panels B–D data are expressed as percentage of each lipid specie levels versus total levels of the lipid class analyzed. Graphs represent the mean ± SEM. Statistical analysis was performed by One Way ANOVA test. ^∗p < 0.05 due to aging. ^#p < 0.05 due to Parkin loss.