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. 2019 Apr 24;13:329. doi: 10.3389/fnins.2019.00329

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Copyright © 2019 Gaudioso, Garcia-Rozas, Casarejos, Pastor and Rodriguez-Navarro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autophagy related markers in subcelluar fractions from brain and changes due to aging and parkin loss. p62 accumulates in PK-KO old mice autophagosomes but not in autophagolysosomes or lysosomes. (A) Representative image of a Western-Blot experiment showing p62 levels in the different subcellular fractions isolated. (B) Quantification of p62 intensity in brain’s subcellular fractions. (C) Western-Blot experiment showing LAMP1 and Cathepsin D levels in homogenates and lysosomes. (D) Quantification of Cath D 36 KDa in brain’s subcellular fractions. (E) Quantification of LAMP1 intensity in brain’s subcellular fractions. Graphs represent the mean ± SEM. Statistical analysis was performed by One Way ANOVA test. ^∗p < 0.05 due to aging. ^#p < 0.05 due to Parkin loss. n = 3–5 preparations of three mice each.