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. 2019 Apr 24;10:432. doi: 10.3389/fphys.2019.00432

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Copyright © 2019 Wei, Yuan, Jiang, Lu, Liu, Luo, Huang, Qi and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between rs2666433 polymorphism and serum level of homocysteine. The effect of rs2666433 polymorphism on the serum level of homocysteine in controls and IS patients. (A) Bioinformatics software predicted that MTHFR gene was a target of miR-34a. (B) Increased level of homocysteine in IS patients compared to controls (P < 0.001), especially in IS patients carrying the rs2666433AA compared to those carrying the rs2666433 GG+GA (P < 0.001). The upper and lower boundaries of the boxes represent the 25th and 75th percentiles of the homocysteine value. The upper and lower whiskers represent the maximum and minimum values. The horizontal line within the box represents the median value. MTHFR: methylenetetrahydrofolate reductase; UTR: untranslated region.